Title of article :
Highlights from the first symposium on upper tract urothelial carcinoma
Author/Authors :
Matin، نويسنده , , Surena F. and Shariat، نويسنده , , Shahrokh F. and Milowsky، نويسنده , , Matthew I. and Hansel، نويسنده , , Donna E. and Kassouf، نويسنده , , Wassim and Koppie، نويسنده , , Theresa and Bajorin، نويسنده , , Dean and Grollman، نويسنده , , Arthur P.، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2014
Abstract :
AbstractObjectives
tract urothelial carcinoma (UTUC) is a rare disease in Western countries and garners little focused attention in urologic and oncologic circles. We report highlights from the first symposium on UTUC.
s
rticipants were asked to provide a summary of their presentation to be included as part of these proceedings. Submitted summaries were synthesized into this document. All contributors reviewed and provided input on the final draft.
s
ighlights are included in this report, including landmark research that not only reveals the likely cause of Balkan endemic nephropathy and associated UTUC but also links it directly to UTUC in Taiwan. Because of the ubiquitous use of Aristolochia plants in these herbal remedies, a public health problem of considerable magnitude is anticipated in Asian countries. Gene expression signatures reveal some differential expression in bladder carcinoma, such as CLCA2 and GABRE. Few urinary markers have proven utility for the diagnosis and follow-up of UTUC, and no tissue or blood-based markers are currently undergoing clinical application. Novel endoscopic therapies provide some hope of improving tissue sampling, diagnosis, and kidney-sparing therapeutics, but the greatest potential lies in improving clinical (preoperative) risk stratification, which is critically limited in this disease. Biomarkers, currently untested, hold promise in identifying patients most likely to benefit from perioperative chemotherapy and at high risk from cisplatin-induced nephrotoxicity.
sions
e its rarity in the West, UTUC is reaching potentially epidemic proportions in the East because of exposure to carcinogenic herbal remedies. Critical trials are needed to improve our understanding and treatment of UTUC. Because of the broad range of comorbid conditions in patients suffering from this disease, it is the consensus of the participants that future clinical trials should be practical in design and applicable to a broad range of patients, diverging from the current dogma of narrow patient selection criteria in clinical trials. Practical designs would maximize accrual for a still uncommon disease, and their findings would be applicable to a larger proportion of patients than current narrowly selected designs.
Keywords :
Epidemiology , carcinogens , biomarkers , Urothelial carcinoma , Ureteral cancer , Renal pelvis cancer
Journal title :
Urologic Oncology
Journal title :
Urologic Oncology