Author/Authors :
Koh، نويسنده , , Kwang Kon and Ahn، نويسنده , , Jeong Yeal and Choi، نويسنده , , Yu Mi and Han، نويسنده , , Seung-Hwan and Kim، نويسنده , , Dae Sung and Kim، نويسنده , , Hyung Sik and Ahn، نويسنده , , Tae Hoon and Choi، نويسنده , , Soon-Suck and Shin، نويسنده , , Eak Kyun، نويسنده ,
Abstract :
We administered a step I diet to 50 hypercholesterolemic patients with coronary artery disease during 12 weeks. Compared with baseline, the step I diet significantly changed lipoprotein levels, significantly improved the percent flow-mediated dilation response to hyperemia by 32 ± 7% (p <0.001), increased plasma levels of nitrate by 45 ± 12% (p = 0.013), and lowered plasma levels of malondialdehyde by 7 ± 4% (p = 0.011). However, the step I diet did not significantly change serologic markers of inflammation, plaque stability, and thrombosis. Step I diet therapy improved endothelium-dependent vasodilation with an increase in plasma nitrogen oxide and a decrease in oxidant stress in hypercholesterolemic patients with coronary artery disease.
