Author/Authors :
Bogaty، نويسنده , , Peter and Dagenais، نويسنده , , Gilles R. and Poirier، نويسنده , , Paul L. Boyer، نويسنده , , Luce and Auclair، نويسنده , , Lucie and Pépin، نويسنده , , Guylaine and Jobin، نويسنده , , Jean and Arsenault، نويسنده , , Marie، نويسنده ,
Abstract :
To investigate whether marked and sustained lipid-lowering in subjects with stable angina pectoris and dyslipidemia reduces exercise-induced myocardial ischemia, 17 subjects were treated with dose-adjusted atorvastatin over 1 year and underwent serial evaluation of exercise electrocardiographic ischemic parameters, serum biomarkers, and brachial artery endothelial function. Endothelial function improved progressively and C-reactive protein, P-selectin, and tissue plasminogen activator inhibitor levels decreased, but there was no decrease in exercise electrocardiographic ischemia.
