Author/Authors :
Cappelli-Bigazzi، نويسنده , , Maurizio and Santoro، نويسنده , , Giuseppe and Battaglia، نويسنده , , Carmine and Palladino، نويسنده , , Maria Teresa and Carrozza، نويسنده , , Marianna and Russo، نويسنده , , Maria Giovanna and Pacileo MD، نويسنده , , Giuseppe and Calabrٍ، نويسنده , , Raffaele، نويسنده ,
Abstract :
Patients with Downʹs syndrome show an increased pulmonary vascular reactivity that could be due to an impaired vascular endothelial function, which is possibly related to increased oxidative stress. In 8 patients with Downʹs syndrome and 9 euploid patients of similar age, endothelium-dependent and -independent vasodilation was studied, measuring brachial flow velocity with an intravascular Doppler flow wire. Patients with Downʹs syndrome showed a significant impairment of endothelial function versus controls. In presence of the antioxidant vitamin C, endothelium-dependent vasodilation in the patients with Downʹs syndrome was only slightly, but not significantly, improved.
