Title of article :
Effect of edaravone, a novel free radical scavenger, on endothelium-dependent vasodilation in smokers
Author/Authors :
Jitsuiki، نويسنده , , Daisuke and Higashi، نويسنده , , Yukihito and Goto، نويسنده , , Chikara and Kimura، نويسنده , , Masashi and Noma، نويسنده , , Kensuke and Hara، نويسنده , , Keiko and Nakagawa، نويسنده , , Keigo and Oshima، نويسنده , , Tetsuya and Chayama، نويسنده , , Kazuaki and Yoshizumi، نويسنده , , Masao، نويسنده ,
Abstract :
The forearm blood flow (FBF) responses to acetylcholine and to sodium nitroprusside were evaluated before and after administration of edaravone in 10 smokers and 10 nonsmokers. FBF response to acetylcholine was lower in smokers than in nonsmokers. The vasodilatory effects of sodium nitroprusside were similar in both groups. Co-infusion of edaravone increased the FBF response to acetylcholine in smokers, but did not affect the FBF response to acetylcholine in nonsmokers. The administration of NG-monomethyl-l-arginine abolished edaravone-induced augmentation of the FBF response to acetylcholine in smokers. The antioxidative agent edaravone increases nitric oxide mediated vasodilation through a decrease in oxidative stress.
