Author/Authors :
Kenneth C. Bilchick، نويسنده , , Kenneth and Viitasalo، نويسنده , , Matti and Oikarinen، نويسنده , , Lasse and Fetics، نويسنده , , Barry and Tomaselli، نويسنده , , Gordon and Swan، نويسنده , , Heikki and Laitinen، نويسنده , , P.نivi J. and Vننnنnen، نويسنده , , Heikki and Kontula، نويسنده , , Kimmo and Berger، نويسنده , , Ronald D.، نويسنده ,
Abstract :
The investigators sought to test whether certain long QT syndrome (LQTS) mutations are associated with increased repolarization lability and whether repolarization lability (quantified by the QT variability index [QTVI]) is increased in patients with LQTS compared with controls. In 32 genotyped patients with LQTS type 1 (LQT1), 32 genotyped patients with LQTS type 2 (LQT2), and 32 controls, the QTVI was increased in patients with LQT2 (−0.973 ± 0.394, p = 0.01 vs controls) and in patients with LQT1 with mutations other than KCNQ1-FIN (−0.942 ± 0.264, p = 0.04 vs controls) but was similar between the KCNQ1-FIN group and controls.
