Effect of serum albumin on QRS wave amplitude in patients free of heart disease

We studied 193 patients free of heart disease to determine the relation between QRS amplitude and serum albumin. Although there were no significant differences in echocardiographic indexes between the 2 groups, albumin (35.1 ± 4.3 vs 40.1 ± 3.2 g/L) and colloid osmotic pressure (21 ± 4 vs 24 ± 3 mm Hg) were significantly lower in patients with low voltages compared with those without. Moreover, there was a good relation (r = 0.78) between change in QRS amplitude and change in albumin concentration.