Author/Authors :
Takase، نويسنده , , Hiroyuki and Toriyama، نويسنده , , Takayuki and Sugiyama، نويسنده , , Masaya and Nakazawa، نويسنده , , Ai and Hayashi، نويسنده , , Kunihiko and Goto، نويسنده , , Takatoshi and Sugiura، نويسنده , , Tomonori and Ikeda، نويسنده , , Koshiro and Sato، نويسنده , , Koichi and Ueda، نويسنده , , Ryuzo and Dohi، نويسنده , , Yasuaki، نويسنده ,
Abstract :
The effects of nifedipine on inflammation and endothelial function in the coronary circulation were studied in patients who had angina pectoris (n = 17). Long-term treatment with nifedipine (nifedipine CR, 20 mg/day for 4 months) decreased levels of C-reactive protein in the coronary sinus (from 0.35 ± 0.09 mg/dl to 0.07 ± 0.01 mg/dl, mean ± SEM, p <0.05) and enhanced acetylcholine-induced increases in coronary blood flow. Thus, nifedipine is effective in decreasing inflammation and incresing endothelial function in the coronary circulation.
