Stenotic Aortic and Mitral Valves in Three Adult Brothers With Arthrogryposis Multiplex Congenita

Three brothers with arthrogryposis multiplex congenita survived into adulthood. In their fourth decade, the clinical course for each brother became complicated by severe stenoses of their aortic and mitral valves. One brother died suddenly, and the remaining 2 developed heart failure. requiring valvular replacement.