Title of article
Biotransformation of sophoricoside in Fructus sophorae by the fungus Schizophyllum commune
Author/Authors
Wu، نويسنده , , Jianguo and Yang، نويسنده , , Xialu and Ge، نويسنده , , Juan and Zhang، نويسنده , , Yiping and Wu، نويسنده , , Lin and Liu، نويسنده , , Jianmiao and Zhang، نويسنده , , Xiaoyu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2012
Pages
4
From page
496
To page
499
Abstract
Biotransformation of sophoricoside in Fructus sophorae was performed with Schizophyllum commune. Sophoricoside was firstly metabolized to 4′,5,7-trihydroxyisoflavone (2), and then to 4′,7-dihydroxy-5-methoxyisoflavone (3) and 5,7-dihydroxy-4′-methoxyisoflavone (4) as determined by NMR and MS analyzes. The content of compound (2) was increased by more than 30-fold, and compound (3) is a new product that showed good cytotoxic activity with an IC50 of 12.1 nmol/ml against MCF-7 cells.
Keywords
4? , biotransformation , Schizophyllum commune , Fructus Sophorae , Sophoricoside , 7-dihydroxy-5-methoxyisoflavone
Journal title
Bioresource Technology
Serial Year
2012
Journal title
Bioresource Technology
Record number
1928178
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