Author/Authors :
Lu، نويسنده , , Wentong and Senapati، نويسنده , , Dulal and Wang، نويسنده , , Shuguang and Tovmachenko، نويسنده , , Oleg and Singh، نويسنده , , Anant Kumar and Yu، نويسنده , , Hongtao and Ray، نويسنده , , Paresh Chandra، نويسنده ,
Abstract :
As nanotechnology field continues to develop, assessing nanoparticle toxicity is very important for advancing nanoparticles for daily life application. In this Letter, we report the effect of surface coating on cyto, geno and photo-toxicity of silver nanomaterials of different shapes on human skin HaCaT keratinocytes. We found that the citrate coated colloidal silver nanoparticles at 100 μg/mL level are not geno-, cyto- and phtotoxic. On the other hand, citrate coated powder form of the silver nanoparticles are toxic. We have demonstrated that coating of the silver nanoparticles with a biodegradable polymer prevents the toxicity of the powder. Toxicity mechanism has been discussed.
