Author/Authors :
Wang، نويسنده , , Qingyan and Lu، نويسنده , , Guowei and Hou، نويسنده , , Lei and Zhang، نويسنده , , Tianyue and Luo، نويسنده , , Chunxiong and Yang، نويسنده , , Hong and Barbillon، نويسنده , , Grégory and Lei، نويسنده , , Franck H. and Marquette، نويسنده , , Christophe A. and Perriat، نويسنده , , Pascal and Tillement، نويسنده , , Olivier and Roux، نويسنده , , Stéphane and Ouyang، نويسنده , , Qi and Gong، نويسنده , , Qi، نويسنده ,
Abstract :
Dynamic behavior of fluorescent molecules near an individual gold nanoparticle is investigated experimentally by fluorescence correlation spectroscopy method. The gold particle that acts as an optical nano-antenna presents significant near-field volume reduction. The single molecule diffusion behavior is clearly observed within a reduced near-field volume due to a highly localized field enhancement. The near-field volume and fluorescence enhancement are polarization and concentration dependent and strongly depend on the properties of the gold nanoparticle. A simple approximated model is developed to fit the FCS autocorrelation curves. In principle, the single molecule analysis within the near-field volume of nanostructures could be applied to the analysis of biological membranes and intracellular processes.
