Author/Authors :
Castillo، نويسنده , , John J. and Rozo، نويسنده , , Ciro E. and Castillo-Leَn، نويسنده , , Jaime and Rindzevicius، نويسنده , , Tomas and Svendsen، نويسنده , , Winnie E. and Rozlosnik، نويسنده , , Noemi and Boisen، نويسنده , , Anja and Martيnez، نويسنده , , Fernando، نويسنده ,
Abstract :
This Letter involved the preparation of a conjugate between single-walled carbon nanotubes and folic acid that was obtained without covalent chemical functionalization using a simple ‘one pot’ synthesis method. Subsequently, the conjugate was investigated by a computational hybrid method: our own N-layered Integrated Molecular Orbital and Molecular Mechanics (B3LYP(6–31G(d):UFF)). The results confirmed that the interaction occurred via hydrogen bonding between protons of the glutamic moiety from folic acid and π electrons from the carbon nanotubes. The single-walled carbon nanotube-folic acid conjugate presented herein is believed to lead the way to new potential applications as carbon nanotube-based drug delivery systems.
