Controlled-release of ibuprofen on multilayer mesoporous vesicle

A concentric multilayer vesicle with mesoporous channels in each layer was synthesized and used as a drug carrier. The average size of the vesicles was about 100–300 nm, with the cavities of an average distance of about 7 nm between every two layers, and the mesoporous channels of an average diameter of 3.4 nm in each layer. Ibuprofen was selected as the drug model to investigate the vesicleʹs loading and releasing performance. The vesicle showed a fast loading with the ibuprofen capacity (weight ratio of ibuprofen to material) of 30% within 2 h, and a slow controllable release during about 15 h. The Weibull model can be successfully used to describe the release performance. The analysis results demonstrated that fast loading and slow release of the vesicle were mainly attributed to its mesoporous multilayer structure.