Effects of resveratrol and purple grape juice on nucleotide hydrolysis by adult rat serum

ATP, ADP and AMP (adenosine tri, bi and mono-phosphate, respectively) hydrolysis in rat serum were assessed in vitro in the presence of certain flavonoids: resveratrol, quercetin and rutin. Also, the effects of purple grape juice (PGJ) and the effect of PGJ before arginine treatment were observed on serum nucleotide hydrolysis. The in vitro nucleotide hydrolysis by rat serum was increased in the presence of resveratrol for ATP and ADP hydrolysis. There was a decrease of nucleotide hydrolysis in the presence of other flavonoids tested in vitro. The effects of PGJ treatment after 15 days showed that nucleotide hydrolysis increased for ATP, ADP and AMP. We also investigated whether animals that had received injections of arginine and presented reduction of nucleotide hydrolysis activities, would present a retrieval of this reduction by receiving PGJ before injections were administered. Evidently resveratrol may increase nucleotide hydrolysis by serum and PGJ may be capable of preventing the decrease in nucleotide hydrolysis caused by arginine treatment.