Title of article :
Polysaccharides derived from Lycium barbarum suppress IGF-1-induced angiogenesis via PI3K/HIF-1α/VEGF signalling pathways in MCF-7 cells
Author/Authors :
Huang، نويسنده , , Xu and Zhang، نويسنده , , Qing-Yuan and Jiang، نويسنده , , Qiu-Ying and Kang، نويسنده , , Xin-Mei and Zhao، نويسنده , , Ling، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2012
Pages :
6
From page :
1479
To page :
1484
Abstract :
Lycium barbarum (LB) is a berry-type fruit. Lycium barbarum polysaccharides (LBPs), derived from LB, has anti-tumour properties and exhibits potent anti-angiogenic effects. The aim of this study was to elucidate possible signal transduction pathways functioning to mediate the breast cancer-suppressive effects of LBPs. Using MCF-7 cells, we determined that a 90 h treatment with 0.50 mg/ml of LBPs resulted in significant inhibition of cell proliferation. Using this same system, we observed that LBPs could also affect insulin-like growth factor (IGF)-1 protein accumulation, suppress phosphatidylinositol 3-kinase (PI3K) activity and phosphorylated-PI3K (p-PI3K) protein levels, inhibit hypoxia-inducible factor-1 (HIF-1α) protein accumulation without altering HIF-1α mRNA levels, and suppress VEGF mRNA expression and protein production. Our results demonstrate that LBPs may inhibit tumour cell growth by suppressing IGF-1-induced angiogenesis via PI3K/HIF-1α/VEGF signalling pathways.
Keywords :
Angiogenesis , LBPS , IGF-1 , VEGF , breast cancer , HIF-1? , PI3K
Journal title :
Food Chemistry
Serial Year :
2012
Journal title :
Food Chemistry
Record number :
1967236
Link To Document :
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