Author/Authors :
Shahlaei، Mohsen نويسنده , , Hassanzadeh، Farshid نويسنده , , Emami، Jaber نويسنده , , Sohrabi، Ehsan نويسنده Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical sciences, Isfahan University of Medical Sciences, 81746-73461 Isfahan, Iran , , SAGHAIE، LOTFOLLAH نويسنده ,
Abstract :
Multi-drug therapy in high blood pressure is appreciated to achieve a normal blood pressure. A simple spectrophotometric method based on principal component analysis has been proposed for simultaneous determination of amlodipine (Amd) and metoprolol (Met) in pharmaceutical preparations. Calibration matrix contains 3.402 µgml-1 to 170.130 µg ml-1 amlodipine and 13.7 µg ml-1 to 68.5 µgml-1 metoprolol. The proposed method was validated by using a set of synthetic sample mixtures and subsequently applied to simultaneous determination of amlodipine and metoprolol in different pharmaceutical preparations.
