Title of article
Preparation and characterization of Pluronic/TPGS mixed micelles for solubilization of camptothecin
Author/Authors
Gao، نويسنده , , Yan and Li، نويسنده , , Ling Bing and Zhai، نويسنده , , Guangxi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
6
From page
194
To page
199
Abstract
To increase the solubility and cytotoxicity of poorly soluble anticancer drug camptothecin (CPT), mixed micelles made of Pluronic P105 (P105) and d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) were prepared. The interaction of Pluronic and TPGS was studied and critical micelle concentration (CMC) was used to evaluate the micellar stability towards dilution. Poorly soluble anticancer drug CPT was incorporated into the mixed micelles. The solubility of CPT by the mixed micelles was more than that of the free drug. The cytotoxicity of the CPT-loaded mixed micelles against MCF-7 cancer cell in vitro was remarkably higher than that of the free drug.
Keywords
Mixed micelles , camptothecin , Solubilization and cytotoxicity , Pluronic and TPGS
Journal title
Colloids and Surfaces B Biointerfaces
Serial Year
2008
Journal title
Colloids and Surfaces B Biointerfaces
Record number
1969148
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