Electrochemical behavior of valsartan and its determination in capsules

Electrochemical behavior of valsartan has been carried out in Britton–Robinson (B–R) buffer solution at pH 7.0 at the mercury film electrode (MFE) by cyclic, linear sweep, differential-pulse and square-wave voltammetry. The property of valsartan adsorption at the MFE using accumulation potential of +0.10 V was observed. The effects of experimental parameters on electrochemical process at the MFE were discussed. Differential-pulse adsorptive stripping and square-wave adsorptive stripping voltammetry for the valsartan determination were proposed, linearity was found in the range of 6.0 × 10−8 to 4.0 × 10−6 mol/L. The detection limits were 2.93 × 10−9 and 3.27 × 10−9 mol/L, respectively. The proposed methods were also applied to the commercial valsartan with good recoveries.