Bioavailability of glycitein relatively to other soy isoflavones in healthy young Caucasian men

Glycitein is a Selective Estradiol Receptor Modulator (SERM) from soy. The study reports plasma bioavailability and urine excretion of glycitein compared to other soy isoflavones after a unique intake of food supplement based on soy germ containing 55.24 mg isoflavones. Eighteen plasma and urinary sampling profiles collected over 48 h from healthy young Caucasian men were analysed using specific ELISAs. Eight profiles contained equol. Glycitein Tmax, Cmax, AUC0→24h and T½ in plasma were calculated. Urine Tmax, % of excretion at 24 h and clearance were assessed. Glycitein is one of the best absorbed flavonoids. Plasma steady-state level can be achieved by several intakes a day. Glycitein bioavailability is similar to that of daidzein and its urinary excretion is significantly higher than that of genistein. Equol does not affect glycitein bioavailability. Knowing glycitein bioavailability in man is essential for the development of soy-germ-based food supplements for health applications.