Author/Authors :
Baik، نويسنده , , Hye Jung and Oh، نويسنده , , Nam Muk and Oh، نويسنده , , Young Taik and Yoo، نويسنده , , Na Young and Park، نويسنده , , So Young and Oh، نويسنده , , Kyung Taek and Youn، نويسنده , , Yu Seok and Lee، نويسنده , , Eun Seong، نويسنده ,
Abstract :
Polysaccharidic nanogels were fabricated with bovine serum albumin (BSA) and a glycol chitosan (GCS) grafted with functional 3-diethylaminopropyl (DEAP) groups. These nanogels were investigated to evaulate their cellular uptake in HeLa cells and in vivo fate in nude mice tumor model. Unlike free BSA, GCS-g-DEAP/BSA nanogels improved cellular uptake of BSA. Furthermore, this system led to an enhanced blood circulation and a high accumulation of BSA in the tumor site. Our collective results strongly support that GCS-g-DEAP/BSA nanogel is a potential carrier system for high molecular weight proteins.
Keywords :
Polysaccharidic nanogels , Glycol chitosan , Bovine serum albumin , pH-sensitivity
