Title of article
Magnetic levitating polymeric nano/microparticular substrates for three-dimensional tumor cell culture
Author/Authors
Lee، نويسنده , , Woong Ryeol and Oh، نويسنده , , Kyung Taek and Park، نويسنده , , So Young and Yoo، نويسنده , , Na Young and Ahn، نويسنده , , Yong Sik and Lee، نويسنده , , Don Haeng and Youn، نويسنده , , Yu Seok and Lee، نويسنده , , Deok-Keun and Cha، نويسنده , , Kyung-Hoi and Lee، نويسنده , , Eun Seong، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2011
Pages
6
From page
379
To page
384
Abstract
Herein, we describe magnetic cell levitation models using conventional polymeric microparticles or nanoparticles as a substrate for the three-dimensional tumor cell culture. When the magnetic force originating from the ring-shaped magnets overcame the gravitational force, the magnetic field-levitated KB tumor cells adhered to the surface area of magnetic iron oxide (Fe3O4)-encapsulated nano/microparticles and concentrated clusters of levitated cells, ultimately developing tumor cells to tumor spheroids. These simple cell culture models may prove useful for the screening of anticancer drugs and their formulations.
Keywords
PLLA-b-PEG-folate nanoparticle , PLGA microparticle , iron oxide , Tumor spheroid
Journal title
Colloids and Surfaces B Biointerfaces
Serial Year
2011
Journal title
Colloids and Surfaces B Biointerfaces
Record number
1973089
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