Author/Authors :
Lee، نويسنده , , Hyun Ju and Lee، نويسنده , , Se Guen and Oh، نويسنده , , Eun Jung and Chung، نويسنده , , Ho Yun and Han، نويسنده , , Sang Ik and Kim، نويسنده , , Eun-Jung and Seo، نويسنده , , Song Yi and Ghim، نويسنده , , Han Do and Yeum، نويسنده , , Jeong Hyun and Choi، نويسنده , , Jin Hyun، نويسنده ,
Abstract :
Excellent colloidal stability and antimicrobial activity are important parameters for silver nanoparticles (AgNPs) in a range of biomedical applications. In this study, polyethyleneimine (PEI)-capped silver nanoparticles (PEI-AgNPs) were synthesized in the presence of sodium borohydride (NaBH4) and PEI at room temperature. The PEI-AgNPs had a positive zeta potential of approximately +49 mV, and formed a stable nanocolloid against agglomeration due to electrostatic repulsion. The particle size and hydrodynamic cluster size showed significant correlations with the amount of PEI and NaBH4. PEI-AgNPs and even PEI showed excellent antimicrobial activity against Staphylococus aureus and Klebsiella pneumoniae. The cytotoxic effects of PEI and PEI-AgNPs were confirmed by an evaluation of the cell viability. The results suggest that the amount of PEI should be minimized to the level that maintains the stability of PEI-AgNPs in a colloidal dispersion.
Keywords :
antimicrobial activity , sodium borohydride , stability , cytotoxicity , Silver nanoparticles , polyethyleneimine
