Synthesis of Fe3O4@silica/poly(N-isopropylacrylamide) as a novel thermo-responsive system for controlled release of H3PMo12O40 nano drug in AC magnetic field

In this work, a new method is introduced for synthesis of nano drug for the first time. H3PMo12O40 and Fe3O4@SiO2/poly(N-isopropylacrylamide), were prepared as nano drug and magneto thermally responsive nano-carrier respectively. Then the released behavior of H3PMo12O40 nano-drug from this thermo-responsive carrier was investigated in an AC magnetic field. When a drug particle is broken up to nanometer range, the total surface area is increased; therefore the rate of dissolution and the rate of release are increased. The as-synthesized nanostructures were characterized by scanning electron microscopy (SEM), X-ray powder diffraction (XRD), transmission electron microscopy (TEM), vibrating sample magnetometer (VSM), and Fourier transform infrared spectroscopy (FT-IR). Furthermore, experimental condition which lead to the released profile of H3PMo12O40 nano-drug from Fe3O4@SiO2/poly(N-isopropylacrylamide), such as strength of magnetic field (H), temperature (T), particle size of drug and content of loaded drug were tested. Increasing the strength of magnetic field, temperature and content of loaded drug, the rate of drug release was also increased.