Author/Authors :
Celia، نويسنده , , Christian and Trapasso، نويسنده , , Elena and Locatelli، نويسنده , , Marcello and Navarra، نويسنده , , Michele and Ventura، نويسنده , , Cinzia Anna and Wolfram، نويسنده , , Joy and Carafa، نويسنده , , Maria and Morittu، نويسنده , , Valeria Maria and Britti، نويسنده , , Domenico and Di Marzio، نويسنده , , Luisa and Paolino، نويسنده , , Donatella، نويسنده ,
Abstract :
Citrus extracts, particularly bergamot essential oil (BEO) and its fractions, have been found to exhibit anticancer efficacy. However, the poor water solubility, low stability and limited bioavailability have prevented the use of BEO in cancer therapy. To overcome such drawbacks, we formulated BEO liposomes that improved the water solubility of the phytocomponents and increased their anticancer activity in vitro against human SH-SY5Y neuroblastoma cells. The results warrant further investigation of BEO liposomes for in vivo applications.
Keywords :
natural products , Liposomes , Bergamot essential oil (BEO) , Citrus extracts , CANCER , SH-SY5Y human neuroblastoma cells
