Title of article
Micellar nanoparticles loaded with gemcitabine and doxorubicin showed synergistic effect
Author/Authors
Liu، نويسنده , , Dechun and Chen، نويسنده , , Yanbin and Feng، نويسنده , , Xiaoshan and Deng، نويسنده , , Miao and Xie، نويسنده , , Gangqiang and Wang، نويسنده , , Jianguang and Zhang، نويسنده , , Like and Liu، نويسنده , , Qipeng and Yuan، نويسنده , , Pengfei، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2014
Pages
11
From page
158
To page
168
Abstract
Gemcitabine and doxorubicin were separately chemically linked to biodegradable polymers to prepare polymer–gemcitabine and polymer–doxorubicin conjugates. Moreover, the two conjugates can self-assemble into micelles with both gemcitabine and doxorubicin. In this way, the two anticancer drugs were combined. The in vitro MTT assay with these combined drugs showed synergistic effect compared to single use of each drug.
Keywords
doxorubicin , Gemcitabine , Polymer conjugates , DRUG DELIVERY , micelles
Journal title
Colloids and Surfaces B Biointerfaces
Serial Year
2014
Journal title
Colloids and Surfaces B Biointerfaces
Record number
1977733
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