Author/Authors :
Liu، نويسنده , , Dechun and Chen، نويسنده , , Yanbin and Feng، نويسنده , , Xiaoshan and Deng، نويسنده , , Miao and Xie، نويسنده , , Gangqiang and Wang، نويسنده , , Jianguang and Zhang، نويسنده , , Like and Liu، نويسنده , , Qipeng and Yuan، نويسنده , , Pengfei، نويسنده ,
Abstract :
Gemcitabine and doxorubicin were separately chemically linked to biodegradable polymers to prepare polymer–gemcitabine and polymer–doxorubicin conjugates. Moreover, the two conjugates can self-assemble into micelles with both gemcitabine and doxorubicin. In this way, the two anticancer drugs were combined. The in vitro MTT assay with these combined drugs showed synergistic effect compared to single use of each drug.
Keywords :
doxorubicin , Gemcitabine , Polymer conjugates , DRUG DELIVERY , micelles
