Author/Authors :
Srinivas Ashok Kumar، Bagepalli نويسنده Department of Pharmacognosy, Sri K.V.College of Pharmacy, Chickballapur , , Lakshman، Kuruba نويسنده Department of Pharmacognosy, PES College of Pharmacy, Bangalore , , Konta Narsimha Jayaveera، Korala نويسنده Department of Chemistry, Jawaharlal Nehru Technological University of College of Engineering, Anantapur , , Sheshadri Shekar، Devangam نويسنده Department of Pharmacology, Sri K.V.College of Pharmacy, Chickballapur , , SwamyVel Muragan، Chinna نويسنده Department of Pharmacology, Sri K.V.College of Pharmacy, Chickballapur , , Manoj، Bachappa نويسنده Department of Pharmacognosy, Sri K.V.College of Pharmacy, Chickballapur ,
Abstract :
Methanolic extract of whole plant of Amaranthus viridis L (MEAV), was screened for antinociceptive activity using acetic acid induced writhing test, hot plate test and tail immersion test in mice. In a similar way a screening exercise was carried out to determine the antipyretic potential of the extract using yeast induced pyrexia method in rats. Administration of the extracts was applied to both laboratory animals at the doses of 200 and 400 mg/kg body weight, respectively. The results of the statistical analysis showed that MEAV had significant (p<0.01) dose dependent antinociceptive and antipyretic properties at 200 and 400 mg/kg. Hence present investigation reveals the antinociceptive and antipyretic activities of methanolic extract of Amaranthus viridis.
