Author/Authors :
Nasiri، Mahboobeh نويسنده Department of Natural Sciences, Arsanjan Branch, Islamic Azad University, Arsanjan, Iran Nasiri, Mahboobeh , Roostaei، Ali نويسنده Department of Microbiology, Science and Research Branch, Islamic Azad University, Fars, Iran Roostaei, Ali , Ehsanian، Zeinab نويسنده Department of Natural Sciences, Arsanjan Branch, Islamic Azad University, Arsanjan, Iran Ehsanian, Zeinab
Abstract :
Background: The association between Methylene tetrahydrofolate reductase polymorphism and Coronary Artery diseases risk has been both confirmed and refuted in a number of published studies. The aim of this study was to investigate whether genetic polymorphisms of MTHFR (C677T, A1298C) contributed to the development of myocardial infarction (MI). Material and Methods: The present case-control study consisted of 54 patients with a history of MI and 54 gender-matched normal controls. The SNPs genotypes were determined using polymerase chain reaction followed by restriction fragment length polymorphism method. Results: No significant association of the MTHFR A1298C with the risk of MI was observed. However, the allele frequencies of C677T SNP differed significantly among patients and controls (0.83 vs. 0.30). A strong positive relationship between the TT genotype and the risk of MI supported with a significant p-value < 0.001 (OR= 11.87, 95% CI: 4.7- 29.9, p < 0.001). Conclusions: The results of the present study show the importance of C677T SNP as a potential biomarker for screening susceptible cases to MI.
