Author/Authors :
Bari، S.B. نويسنده 1Department of Pharmaceutical Chemistry, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur - 425 405 (MS) India , , Agrawal، A.O. نويسنده 1Department of Pharmaceutical Chemistry, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur - 425 405 (MS) India , , Patil، U.K. نويسنده 2Department of Microbiology, R. C. Patel College of Arts, Science, Commerce, Shirpur - 425 405 (MS) India ,
Abstract :
In the present work, a series of new 5-substituted-3-(4-arylimino)-1-[5-mercapto(1,3,4-oxadiazolyl)]-methyl-indol-2-one (4a-g) have been synthesized by heterocyclization of 5-substituted-3-(4-arylimino)-2-oxo-1-indole acetylhyrazide (3a-g) on treatment with CS2 in ethanolic KOH. The compound 4a was characterized by its elemental analysis, IR, 1HNMR and Mass Spectroscopy. The synthesized compounds (4a-g) were evaluated for in vitro antibacterial activity and antifungal activity against various strains of bacteria and fungi.
