Author/Authors :
سجادي خواه، سجاد نويسنده Department of Chemistry, Faculty of Science, The University of Sistan & Baluchestan, P. O. Box 98135-674 Zahedan, Iran Sajadikhah, Seyed Sajad , مقصود لو، مالك طاهر نويسنده Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P.O. Box 98135-674 Zahedan, I.R. of Iran Maghsoodlou, Malek Taher , حاضري، نوراله نويسنده دانشگاه سيستان و بلوچستان , , محمديان-سوري، سجاد نويسنده Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P.O. Box 98135-674 Zahedan, I.R. of Iran Mohammadian-Souri, Sajad
Abstract :
A mixture of commercial lime juice and ethanol – without any additive - was found to be a natural, biodegradable
and highly efficient medium for the extremely facile one-pot synthesis of highly functionalized dihydropyrrol-2-ones from the
four-component domino reaction of amines, dialkyl acetylenedicarboxylates and formaldehyde at ambient temperature. The
salient advantages of this method are eco-friendly and mild reaction conditions, green solvent, inexpensive and available
material, good to high yields, short reaction times, simple work-up and lack of need for column chromatography.
