pH-sensitive nano carriers for oral-curcumin delivery

The aim of this study is to utilize the nano carriers for oral delivery of curcumin (Cur). In the first, Modified Nano Silica particles (MNS) and Nano Chitosan (NCs) were synthesized, and then the curcumin natural compound covalently attached to these carriers. The composition of the nano carriers containing curcumin was determined by FTIR spectroscopy. The in vitro curcumin release profiles were established separately in both enzyme-free simulated gastric and intestinal fluids (SGF, pH=1) and (SIF, pH=7.4), respectively. Detection of hydrolysis solution by UV-Vis spectroscopy at selected intervals showed that the curcumin can be released by hydrolysis of the imine bond between the curcumin and nano carriers in low rate. This study showed us, the degree of hydrolysis in MNS-Cur and NCs-Cur increases in acidic pH because of carriersʹ high surface.