Author/Authors :
Memar، Bahram نويسنده , , Aledavood، seyed AMIR نويسنده Cancer Research Center , Mashhad University of Medical Sciences, Mashhad, Iran , , ShahidSales، Soodabeh نويسنده Assistant Professor of Radiotherapy and Oncology , , Ahadi، Mitra نويسنده Dept. of Radiation oncology, Cancer Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran , , Farzadnia، Mahdi نويسنده , , Raziee، Hamid Reza نويسنده , , Noori، Sedighe نويسنده Medical Student, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Noori, Sedighe , Tayebi-Meybodi، Naser نويسنده Dept. of Pathology, Imam Reza Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Tayebi-Meybodi, Naser , AMOUIAN، SAKINEH نويسنده , , Mohtashami، Samira نويسنده Dept. of Radiation oncology, Cancer Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran ,
Abstract :
Background: B-cell non-Hodgkin’s lymphoma (NHL) is a common malignancy of lymphoid tissues. Different types of NHL show various behaviors, prognoses, and responses to treatment. Evaluation of disease activity in NHL can be helpful in managing and even increasing the patient’s survey.
Methods and Results: In total, 121 patients (76 males and 45 females), and their age range were 18-53 years, were evaluated in this study. The mean level of serum carbohydrate antigen 125 (CA-125) was 89.3±18.5 u/ml, ranging from 27 to 135 u/ml. There were significant differences in International Prognostic Index (IPI) score (p=0.002), stage of the disease (p=0.006), mortality rate (p=0.02), and relapse rate (p=0.04) between patients with serum CA-125 level < 35 u/ml and patients with CA-125 level > 35 u/ml.
Conclusion: CA-125 seems to be a useful and reliable tumor marker for monitoring a patient with NHL. It might be the time to consider CA-125 in staging, prognostic scoring, or decision making about NHL treatment.
