Measurement of solubility of erythromycin acetone solvate in aqueous acetone solution between 298 K and 323 K

Using a laser monitoring observation technique, the solubility of erythromycin acetone solvate in binary acetone + water solvent mixtures was measured by a synthetic method at temperatures ranging from 298.00 K to 323.00 K and at atmosphere pressure. The results of these measurements were correlated by the combined nearly ideal binary solvent CNIBS/Redlich–Kister equation and the modified Apelblat equation, respectively. For the solubility data studied, the CNIBS/Redlich–Kister equation was found to provide a more accurate mathematical representation of the experimental data.