Association of Inflammatory Mediators with Coronary Artery Disease in Diabetic Patients

Background and Objectives:Coronary artery disease (CAD) is regarded as the leading cause of morbidity and mortality around the world.Diabetes mellitus (DM) is associated with the development of CAD and increased risk of morbidity and mortality.The goal of this study was to assess the association of tumor necrosis factor? (TNF-?) and high sensitivity C-reactive protein (hsCRP) with CADseverity in diabetic patients. Materials & Methods:The cross-sectional protocol of this research was conducted on the referrals (n=81) of Chamran and Alzahrahospitals (Isfahan, Iran) in 2012. The severity of CAD was determined using angiographic findings and Gensini scoring system. TNF-?andhsCRP were measured in addition to some routine parameters. For statistical analysis, Chi-square test was used. Results:Of the patients, 57 were male (70.3%) and 24 (29.6%) were female with a mean age of 54.2 years. In addition, a significant relationship was found out between the severity of CAD and level of hsCRP and TNF? (p < 0.05-0.01). Conclusion:Markers of inflammatory mediators like hsCRP and TNF? are strongly associated with CAD in diabetic patients that have clinically highprognostic value.