Author/Authors :
Maleki Dizaj، Solmaz نويسنده Student Research Committee, Tabriz University of Medical Science, Tabriz, Iran , , Mennati، Afsaneh نويسنده Faculty of Science, Physical Chemistry Group, Uremia Payam Noor University, Uremia, Iran. , , Jafari، Samira نويسنده Phase Equilibria Research Laboratory, Department of Chemistry, Faculty of Science, University of Zanjan, P.O. Box 45195-313 Zanjan, I.R. IRAN , , Khezri، Khadejeh نويسنده Faculty of Science, Physical Chemistry Group, Uremia Payam Noor University, Uremia, Iran. , , Adibkia، Khosro نويسنده ,
Abstract :
Due to the vast and inappropriate use of the antibiotics, microorganisms have begun to develop resistance to the commonly used antimicrobial agents. So therefore, development of the new and effective antimicrobial agents seems to be necessary. According to some recent reports, carbon-based nanomaterials such as fullerenes, carbon nanotubes (CNTs) (especially single-walled carbon nanotubes (SWCNTs)) and graphene oxide (GO) nanoparticles show potent antimicrobial properties. In present review, we have briefly summarized the antimicrobial activity of carbon-based nanoparticles together with their mechanism of action. Reviewed literature show that the size of carbon nanoparticles plays an important role in the inactivation of the microorganisms. As major mechanism, direct contact of microorganisms with carbon nanostructures seriously affects their cellular membrane integrity, metabolic processes and morphology. The antimicrobial activity of carbon-based nanostructures may interestingly be investigated in the near future owing to their high surface/volume ratio, large inner volume and other unique chemical and physical properties. In addition, application of functionalized carbon nanomaterials as carriers for the ordinary antibiotics possibly will decrease the associated resistance, enhance their bioavailability and provide their targeted delivery.
