Title of article :
Improved synthesis of 3-(dialkylaminomethyl)-indole in acetic acid aqueous solution under ultrasound irradiation
Author/Authors :
Li، نويسنده , , Ji-Tai and Sun، نويسنده , , Shaofeng and Sun، نويسنده , , Ming-Xuan، نويسنده ,
Abstract :
Synthesis of Mannich bases related to gramine via Mannich reaction of secondary amine, formaldehyde and indole or N-methylindole can be carried out in 69–98% yields in acetic acid aqueous solution at 35 °C under ultrasound irradiation. Compared with the method using stirring, the present procedure provided several advantages such as milder conditions, shorter reaction time and higher yield.
Keywords :
Gramine , Synthesis , Ultrasound , Mannich reaction
Journal title :
Astroparticle Physics
