Author/Authors :
Martins، نويسنده , , Marcos A.P. and Rossatto، نويسنده , , Marcelo and Prola، نويسنده , , Liziê D.T. and Pizzuti، نويسنده , , Lucas and Moreira، نويسنده , , Dayse N. and Campos، نويسنده , , Patrick T. and Frizzo، نويسنده , , Clarissa P. and Zanatta، نويسنده , , Nilo and Bonacorso، نويسنده , , Helio G.، نويسنده ,
Abstract :
The synthesis of 14 novel N-propargylic β-enaminones from the reaction of β-alkoxy vinyltrihalomethyl[carboxyethyl] ketones [R3C(O)CHC(R1)OMe, where R3 = CF3, CCl3, CO2Et and R1 = Me, Et, Pr, Bu, i-Pent, CH2CH2CO2Me] with propargyl amines [R2NHCH2CCH, where R2 = Pr, PhCH2] is reported. Yields, solvents and reaction times needed for reaction completion, by microwave irradiation (MW), conventional thermal heating (TH) and under ultrasound irradiation (US) are compared. The best results were obtained under US irradiation in good to excellent yields (70–93%).
Keywords :
enones , Enaminones , Propargyl amines , N-Propargylic ?-enaminones
