Author/Authors :
-، - نويسنده Department of pediatrics, Associate Professor of Neonatology, Mashhad University of Medical Sciences,Mashhad, Iran Saeidi, Reza , -، - نويسنده Department of pediatrics, Fellow of neonatology, Mashhad University of Medical Sciences , Mashhad, Iran Gharaee, Reza , -، - نويسنده Rheumatologist, Mashhad University of Medical Sciences , Mashhad, Iran Nobakht, Zohreh
Abstract :
Neonatal purpura fulminans is a rare and life threatening disease that can be inherited or acquired in etiology. It manifests as DIC and extensive subcutaneous thrombosis. The condition is often fatal unless there is prompt diagnosis, and judicious therapy. The most important causes of this condition are infections and congenital deficiency of anticoagulant proteins C and S.In the case of PC (protein C) deficiency,the management includes an acute phase of replacement therapy with fresh frozen plasma (FFP) or protein C concentrate and a maintenance therapy that includes anticoagulation with Warfarin or low molecular weight heparin. Here we report a case of neonatal purpura fulminans due to suspected protein C deficiency.
