Author/Authors :
Woody، نويسنده , , C. and Vaska، نويسنده , , P. and Schlyer، نويسنده , , D. and Pratte، نويسنده , , Bipin Junnarkar، نويسنده , , S. and Park، نويسنده , , S.-J. and Stoll، نويسنده , , S. and Purschke، نويسنده , , M. and Southekal، نويسنده , , S. and Kriplani، نويسنده , , A. and Krishnamoorthy، نويسنده , , S. and Maramraju، نويسنده , , S. and Lee، نويسنده , , D. and Schiffer، نويسنده , , W. Scott Dewey، نويسنده , , S. and Neill، نويسنده , , J. and Kandasamy، نويسنده , , A. and O’Connor، نويسنده , , P. and Radeka، نويسنده , , V. and Fontaine، نويسنده , , R. and Lecomte، نويسنده , , R.، نويسنده ,
Abstract :
The RatCAP is a small, head-mounted PET tomograph designed to image the brain of a conscious rat without the use of anesthesia. The detector is a complete, high-performance 3D tomograph consisting of a 3.8 cm inside-diameter ring containing 12 block detectors, each of which is comprised of a 4×8 array of 2.2×2.2×5 mm3 LSO crystals readout with a matching APD array and custom ASIC, and has a 1.8 cm axial field of view. Construction of the first working prototype detector has been completed and its performance characteristics have been measured. The results show an intrinsic spatial resolution of 2.1 mm, a time resolution of ∼14 ns FWHM, and a sensitivity of 0.7% at an energy threshold of 150 keV. First preliminary images have been obtained using 18F-FDG and 11C-methamphetamine, which show comparable image quality to those obtained from a commercial MicroPET R4 scanner. Initial studies have also been carried out to study stress levels in rats wearing the RatCAP.
