Title of article :
Seminal Levels of Pro-inflammatory (CXCL1, CXCL9, CXCL10) and Homeostatic (CXCL12) Chemokines in Men With Asymptomatic Chlamydia trachomatis Infection
Author/Authors :
Hakimi ، Hamid نويسنده Dept. of Microbiology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. , , Zainodini، Nahid نويسنده Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, IR Iran , , Khorramdelazad، Hossein نويسنده Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, IR Iran , , Arababadi، Mohammad Kazemi نويسنده Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, IR Iran , , HASSANSHAHI، GHOLAMHOSSEIN نويسنده ,
Abstract :
Background: Chemokines play important roles in immune system activation against microbial infections.
Objectives: The current study aimed to evaluate seminal levels of CXC chemokines CXCL1, CXCL9, CXCL10 and CXCL12 in Chlamydia trachomatis infected patients.
Materials and Methods: The C. trachomatis infection was determined employing Polymerase Chain Reaction (PCR)-based methods. Seminal concentrations of CXCL1, CXCL9, CXCL10 and CXCL12 were measured by Enzyme-Linked Immunosorbent Assay (ELISA).
Results: The current study results demonstrated that the semen levels of CXCL1 and CXCL9, but not CXCL10 and CXCL12, significantly increased in C. trachomatis infected patients compared to the healthy controls.
Conclusions: Based on the current study results, it may be concluded that both CXCL1 and CXCL9 play more important roles than CXCL10 and CXCL12 in induction of immune responses against C. trachomatis and could possibly be considered as future targets for immunotherapy of C. trachomatis infection.
