Author/Authors :
Cusanno، نويسنده , , F. and Cisbani، نويسنده , , E. and Colilli، نويسنده , , S. and Fratoni، نويسنده , , R. Skip Garibaldi، نويسنده , , F. and Giuliani، نويسنده , , F. and Gricia، نويسنده , , M. and Lo Meo، نويسنده , , S. and Lucentini، نويسنده , , M. and Magliozzi، نويسنده , , M.L. and Santavenere، نويسنده , , F. and Lanza، نويسنده , , R.C. and Majewski، نويسنده , , S. and Cinti، نويسنده , , M.N. and Pani، نويسنده , , R. De Pellegrini، نويسنده , , R. and Orsini Cancelli، نويسنده , , V. and De Notaristefani، نويسنده , , F. and Bollini، نويسنده , , D. and Navarria، نويسنده , , F. and Moschini، نويسنده , , G.، نويسنده ,
Abstract :
Molecular imaging with radionuclides is a very sensitive technique because it allows to obtain images with nanomolar or picomolar concentrations. This has generated a rapid growth of interest in radionuclide imaging of small animals. Indeed radiolabeling of small molecules, antibodies, peptides and probes for gene expression enables molecular imaging in vivo, but only if a suitable imaging system is used. Detecting small tumors in humans is another important application of such techniques. In single gamma imaging, there is always a well known tradeoff between spatial resolution and sensitivity due to unavoidable collimation requirements. Limitation of the sensitivity due to collimation is well known and affects the performance of imaging systems, especially if only radiopharmaceuticals with limited uptake are available. In many cases coded aperture collimation can provide a solution, if the near field artifact effect can be eliminated or limited. At least this is the case for “small volumes” imaging, involving small animals. In this paper 3D-laminography simulations and preliminary measurements with coded aperture collimation are presented. Different masks have been designed for different applications showing the advantages of the technique in terms of sensitivity and spatial resolution. The limitations of the technique are also discussed.
