Title of article
Oxidation of Meloxicam by Streptomyces griseus
Author/Authors
-، - نويسنده Department of Microbiology, Kakatiya University, Warangal-506009, Andhra Pradesh, India Gurram, Shyam , -، - نويسنده Department of Microbiology, Kakatiya University, Warangal-506009, Andhra Pradesh, India Rama, Preethi , -، - نويسنده Department of Microbiology, Kakatiya University, Warangal-506009, Andhra Pradesh, India Sivadevuni, Girisham , -، - نويسنده Department of Microbiology, Kakatiya University, Warangal-506009, Andhra Pradesh, India Solipuram, Madhusudan
Issue Information
فصلنامه با شماره پیاپی 0 سال 2009
Pages
96
From page
47
To page
142
Abstract
-
Abstract
The aim of the present investigation was to biotransform the anti-inflammatory compound meloxicam by enzymes present in whole cells of five actinomycete cultures to produce novel bioactive derivatives. Among the actinomycetes screened, Streptomyces griseus NCIM 2622 was found to possess the enzyme system(s) that oxidize meloxicam into two metabolites whereas that present in S. griseus NCIM 2623 could oxidize meloxicam to only one metabolite in significant quantities. The formation of enzymatic metabolites was monitored and confirmed by high-performance liquid chromatography (HPLC) analysis. The structures were elucidated based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) data and previous reports as 5-hydroxymethyl meloxicam and 5-carboxy meloxicam. From the results obtained in this study, it can be concluded that S. griseus NCIM 2622 possesses oxidizing enzymes, which can be employed to oxidize meloxicam.
Journal title
Iranian Journal of Biotechnology (IJB)
Serial Year
2009
Journal title
Iranian Journal of Biotechnology (IJB)
Record number
2037030
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