Design of a Novel Nano-Sensor for Determination of Acetaminophen

The Fe3O4 nanoparticles coated with silica nanoparticles were prepared, the obtained Fe3O4@SiO2 have uniform spherical morphology with a mean diameter of about 30 nm. Then an electrochemical sensor based on with Fe3O4@SiO2 nanoparticles –coated poly (diallyldimethylammonium chloride) (PDDA)- carbon nanotube (Fe3O4@SiO2 -PDDA-CNT) nanocomposite was fabricated for sensitive detection of acetaminophen. The samples were characterized by means of transmission electron microscopy (TEM) and Fourier transform infrared spectroscopy (FT-IR), Cyclic voltammetry (CV) was used to investigate the electrocatalytic ability of acetaminophen on the Fe3O4@SiO2- PDDA-CNT/ GCE, and differential pulse voltammetry (DPV) was used for the quantification of acetaminophen.