Author/Authors :
McKenzie، نويسنده , , Ian F.C and Apostolopoulos، نويسنده , , Vasso and Lees، نويسنده , , Catherine and Xing، نويسنده , , P.-X and Lofthouse، نويسنده , , Shari and Osinski، نويسنده , , Carla and Popovski، نويسنده , , Violeta and Acres، نويسنده , , Bruce and Pietersz، نويسنده , , Geoff، نويسنده ,
Abstract :
It is desirable to be able to produce either T1 or T2 responses and we have found that, in mice, mannose - coupled antigens stimulated T2 type responses (antibodies and CTLs) whereas if oxidized, mannose - coupled antigens stimulated T1 responses (little antibody and a potent CTL response). In addition, the cytokine profiles support the T1/T2 differentiation with these immunizations, in that oxidized mannan antigen gives IFNγ, IL-2 and IL-12 production, whereas in the absence of oxidization, IL-4 and not the other cytokines is produced. A number of antigens have been examined - particularly Mucin 1 and the delivery method using mannose may be applicable to the other antigens.
