Title of article
Identification of MCP/CD46 analogue on bovine erythrocytes using the new monoclonal antibody IVA-520
Author/Authors
Antal?kov?، نويسنده , , Jana and Simon، نويسنده , , Michal and Jankovi?ov?، نويسنده , , Jana and Horovsk?، نويسنده , , ?ubica، نويسنده ,
Pages
5
From page
155
To page
159
Abstract
MCP/CD46 is a widely distributed C3b/C4b binding regulatory glycoprotein of the complement system that has been identified on all human peripheral blood cells except erythrocytes. In this paper, we describe the identification of bovine CD46 on all blood cells, including erythrocytes, with the newly prepared monoclonal antibody IVA-520. This antibody cross-reacts with human and pig cells. Furthermore, the molecule identified by IVA-520 functionally behaves as the MCP molecule, showing cofactor activity for the factor I-mediated cleavage of bovine C3 complement factor.
Keywords
monoclonal antibody , Bovine , MCP/CD46
Journal title
Astroparticle Physics
Record number
2056352
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