Title of article
Immunostimulatory CpG oligodeoxynucleotides enhance the induction of bovine CD4+ cytotoxic T-lymphocyte responses against the polymorphic immunodominant molecule of the protozoan parasite Theileria parva
Author/Authors
Graham ، نويسنده , , Simon P. and Saya، نويسنده , , Rosemary and Awino، نويسنده , , Elias and Ngugi، نويسنده , , Daniel and Nyanjui، نويسنده , , John K. and Hecker، نويسنده , , Rolf and Taracha، نويسنده , , Evans L.N. and Nene، نويسنده , , Vishvanath D.، نويسنده ,
Pages
7
From page
383
To page
389
Abstract
Enhancement of the induction of cytotoxic T-cell responses by immunostimulatory CpG oligodeoxynucleotides has been described in humans and mouse models. The present study attempted to address whether CpG has a similar effect in cattle. Immunisation of cattle with a recombinant form of the polymorphic immunodominant molecule from Theileria parva emulsified with immunostimulatory CpG oligodeoxynucleotides in adjuvant had no effect on the induction of antibody responses including the isotype profile, but significantly enhanced the induction of cytolytic responses that were mediated by CD4+CD3+ T cells utilizing the perforin-granzyme pathway.
Keywords
Theileria parva , Cytotoxic T Lymphocytes , CpG , Vaccination , cattle
Journal title
Astroparticle Physics
Record number
2056423
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