Author/Authors :
Florins، نويسنده , , Arnaud and Boxus، نويسنده , , Mathieu and Vandermeers، نويسنده , , Fabian and Verlaeten، نويسنده , , Olivier and Bouzar، نويسنده , , Amel-Baya and Defoiche، نويسنده , , Julien and Hubaux، نويسنده , , Roland and Burny، نويسنده , , Arsène and Kettmann، نويسنده , , Richard and Willems، نويسنده , , Luc، نويسنده ,
Abstract :
Bovine leukemia virus (BLV) is a deltaretrovirus that infects and induces accumulation of B-lymphocytes in the peripheral blood and lymphoid tissues of cattle, leading to leukemia/lymphoma. BLV can also be experimentally transmitted to sheep, in which disease appears earlier and at higher frequencies. Abnormal accumulation of leukemic B-lymphocytes results from an alteration of different parameters that include cell proliferation and death as well as migration to lymphoid tissues. Interestingly, B lymphocyte turnover is increased in BLV-infected sheep but reduced in cattle, revealing a potential relationship between cell kinetics and disease progression.
Keywords :
Sheep , BLV , lymphocyte , cattle , Cell dynamics
