Title of article
Immunophenotype-related microRNA expression in canine chronic lymphocytic leukemia
Author/Authors
Gioia، نويسنده , , G. and Mortarino، نويسنده , , M. and Gelain، نويسنده , , M.E. and Albonico، نويسنده , , F. and Ciusani، نويسنده , , E. and Forno، نويسنده , , I. and Marconato، نويسنده , , L. and Martini، نويسنده , , V. and Comazzi، نويسنده , , S.، نويسنده ,
Pages
8
From page
228
To page
235
Abstract
MicroRNAs (miRNAs) are posttranscriptional regulatory noncoding RNAs used to profile human hematopoietic tumors. In this study, some mature miRNAs was quantitated in peripheral blood from dogs with chronic lymphocytic leukemia (CLL). Relative expression data were normalised against four endogenous controls (let-7a, miR-17-5p, miR-26b, and miR-223) selected by geNorm analysis. The results revealed distinct miRNA patterns in CLL depending on the immunophenotype. Also in dogs, the different miRNAs expression could reflect developmental lineage and tumor differentiation. The similar genetics, physiology and exposure to environment in dogs and humans make the miRNA expression study in canine CLL attractive for comparative oncology.
Keywords
dog , Whole Blood , Chronic Lymphocytic Leukemia , Immunophenotype , MicroRNA , Quantitative RT PCR
Journal title
Astroparticle Physics
Record number
2061165
Link To Document