CYP1B1 L432V Polymorphism and Lung Cancer Risk in the Iranian Population

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Background: Lung cancer is considered as one of the most frequent cancers worldwide, and has been the cause of more than onemillion mortalities each year. Exposure to tobacco smoke is the primary cause of most lung cancers, since it contains several thousandcompounds, including more than 50 known carcinogens. However, a small fraction of individuals who are exposed to tobacco smokedevelop lung cancer, therefore genetic factors may render some tobacco smokers more susceptible to cancer.Objectives: Genetic polymorphism in genes that encode metabolizing enzymes may be related to diffrentiated susceptibility ofmalignancy. CYP1B1 protein is a member of the more signifiant CYP1 subfamily enzymes, involved in environmental carcinogen metabolicactivation. The most studied polymorphism in CYP1B1 gene includes 4325 C→G, resulting in an amino acid change from leucine to valineamino acid.Materials and Methods: A case-control study (included 65 lung cancer cases and 80 healthy controls) was designed based on the RFLPPCR method to estimate the possible association of this polymorphism with lung cancer susceptibility in the Iranian population.Results: Regarding the distribution of CYP1B1 L432V genotypes, there were no meaningful diffrences among controls and lung cancerpatients, however among patients carrying the CC genotype, tobacco smokers had a considerable elevated risk for lung cancer comparedto those who had the GG genotype.Conclusions: CYP1B1 L432V polymorphism has an important role in lung cancer risk. Therefore, further studies are recommended forinvestigation of other related CYP1B1 gene polymorphisms, their association with affctive genes and regulatory factors in the Iranianpopulation.