Author/Authors :
Faraji-Rad، Mohammad نويسنده , , Khajavi، Mehdi نويسنده Department of Neurosurgery, Emdad Academic Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran , , Arjmand، Mohammad Hassan نويسنده Department of Surgery, Ghaem Academic Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran , , Shajari، Esmat نويسنده Department of Neurosurgery, Ghaem Academic Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran , , Hamidi Alamdari، Daryoush نويسنده Biochemistry and Nutrition Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran ,
Abstract :
Background: Gliomas are the most common primary brain tumors of the central
nervous system. Among a number of different bio-molecular events, molecular
connections between oxidative stress pathways and their development is prevalent.
Oxidative stress is the consequence of an imbalance between pro-oxidant factors and
antioxidant defense. This imbalance may lead to DNA damage and changes in growth
and function of cells in the brain. Many evidences show that reactive oxygen species
in the mammalian brain are directly responsible for cell and tissue function and
dysfunction. A brain tumor is correlated with oxidative stress. In this study, we
determine the pro-oxidant – antioxidant balance in patients with grade IV brain tumors
(glioblastoma multiforme) by the pro-oxidant – antioxidant assay.
Methods: We collected sera from 50 patients with high grade (IV) glioblastoma
multiform and 49 healthy subjects. The pro-oxidant - antioxidant assay was measured.
Results: There was a significant increase in pro-oxidant - antioxidant values in
patients (158.10±85.71 HK unit) compared to the control group (74.54±33.54 HK;
P=0.001.
Conclusion: The pro-oxidant - antioxidant balance assay can show a high level of
pro-oxidants in the sera of patients with glioblastoma which indicates the presence of
oxidative stress in this group.
